Bose Companion speakers. Expensive 2.0 desktop speakers (7k), but for the money and the minimal footprint on your desk, sound quality in nearfield applications is very impressive. Use it with an ipod with a dock connector adapter for best sound quality. I had a T-amp + wharfedales for my initial office setup, but that one had to be cranked up loud to have good sound. I settled on the Companion 2 since you don't need to play them loud to to hear the detail in the music.
But for serious listening at home, I'd steer clear from the Bose Lifestyle systems. . .