I'm using an Asus VX279H with R9-280x card. I dont see any pixelation or any discoloration. Coming from a 24" monitor the only difference i notice is the fan level of the card when playing FPS it goes up to 80% on the 27 while it was just around 60% sa 24 on high settings. Pero I think it was not a very good investment. I should have gotten a 144hz monitor instead