Actually it depends on the source and your player. Sometimes I even appreciate a good 720p mkv running on an HTPC with Splash PRO compared to my PS3 playing a bluray disc. I have also compared a 4K remastered vs a Remuxed MKV and there is really no discernible difference both running on my HTPC with Splash PRO. Maganda sana blind test to tell whether the source is 720p or 1080p.
I remember a blind test done in Streetsmart's house to discern if the source was an mkv or a bluray disc. We didn't get a perfect score. So I think the difference isn't night and day.