In my experience, there is better response when setting the floorstanders to small and using subwoofer on movies. For (stereo) music setting the FS to large and not using subwoofer is better especially jazz, classical music.
My setup: My FS is always set to small, with subwoofer on. For movies I just use any of those yamaha DSPs or DTS standard/expanded. For stereo sources, I just use "pure direct", in this mode FS is automatically set to large and the SW disabled. For dance/R&B, entertainment->Disco gives me that "boom". The FS combines with the SW crossover at 80Hz. Pioneer 30Hz-35Khz FS being driven by yamaha 7.1 AVR.