It's nice that you started a thread on this TV.
The best settings depend on your source.
For SkyCable HD, I use the General scene with Standard Motionflow and Live Color on. In General scene, the noise reduction schemes (which are on) are beneficial because the bitrate of cable TV is relatively low compared to other sources.
For blu-ray movies, I use Gaming scene with Live Color on. This is because noise reduction and motionflow shemes are off in this scene. Blu ray movies are already high picture quality. Noise reduction schemes only soften and reduce the sharpness of the images, while motionflow contradicts the native 24fps framerate of the movie. I just turn Live Color on to make the colors pop and let Triluminos shine.