Can't believe there isn't a thread about this yet.
Shameless is about an alcoholic living on welfare and his brood of 6. His eldest daughter, 21, is the breadwinner and runs the household while the father passes out in gutters or other people's houses. The kids also help out whatever way they can.
I'm currently in the middle of the 3rd season and it's been an entertaining series to watch. There is quite a bit of nudity, BTW, so be warned.
William H. Macy delivers an outstanding performance as part of an outstanding cast of blue-collar characters. It's quite a complex plot and the twists do work. Catch it if you can.